GOLDBIOTICS® ICU

1. Medication and medical procedures

During medical treatments or surgery, medication is often required.
Studies (Nature and research involving over 1,000 non-antibiotic drugs) show that most medications, especially antibiotics, NSAIDs and gastric drugs, have a catastrophic impact on gut microbiota.

As a result, the beneficial effects of the gut flora are lost and recovery may take months.

👉 Administration of GoldBiotics® ICU, preferably starting a few days before and continuing during treatment, significantly limits this damage.

2. Poor stool quality and coprophagia

Dysbiosis (disrupted gut flora) often results in poor stool quality or diarrhoea.
Coprophagia (eating faeces) is a common behaviour in dogs.

A microbial imbalance can alter the smell and taste of faeces, making them more attractive.
In some cases, dogs attempt to reintroduce beneficial bacteria through faeces.

👉 GoldBiotics® ICU helps restore gut balance and reduces diarrhoea and coprophagia.

3. Behavioural issues and stress

The gut microbiota influences the gut–brain axis and is closely connected to the nervous system.
A disturbed microbiome may lead to depression, anxiety or aggressive behaviour.

👉 GoldBiotics® ICU contributes to a more stable mood and improved stress resilience.

The gut–brain axis transmits signals from the microbiome to the brain via nerves, hormones and metabolites.
Dysbiosis is often associated with increased stress, sleep disturbances and behavioural changes.

Normalisation of the gut microbiota supports mood, stress tolerance, focus and alertness.

👉 GoldBiotics® ICU increases the production of volatile fatty acids that communicate with the nervous system and can even cross the blood–brain barrier.

4. Skin, joints and liver

• Skin: Allergic or atopic dogs often show disrupted gut flora, contributing to inflammation and skin problems.

• Joints: Dysbiosis can exacerbate joint inflammation and arthritis. Studies show that restoring gut flora reduces symptoms.

• Liver: An unhealthy microbiome can impair liver function and lead to toxin accumulation (e.g. fatty liver, hepatitis).

👉 GoldBiotics® ICU helps prevent skin issues, supports joint health and optimises liver function.

5. Immunity and gut dysbiosis

• 70% of immune function depends on gut microbiota.

• Dysbiosis weakens immune defences, increasing susceptibility to infections (e.g. parvovirus, gastro-enteritis).

• Allergies and autoimmune diseases are also linked to disturbed gut flora.

👉 GoldBiotics® ICU strengthens immune resistance by restoring gut microbiota balance.

6. Inflammation and inflamm-aging

Inflammation is a normal protective response, but becomes harmful when chronic.
Chronic inflammation contributes to heart disease, diabetes, cancer and ageing (inflamm-aging).

👉 GoldBiotics® ICU reduces inflammatory responses and helps slow ageing processes.

7. IBD and high blood glucose

IBD (Inflammatory Bowel Disease) causes chronic intestinal inflammation, diarrhoea, abdominal pain, weight loss and fatigue.
Hyperglycaemia (high blood sugar) results from insulin dysregulation.

Although not directly linked, IBD patients have a higher risk of type 2 diabetes and hyperglycaemia.

👉 GoldBiotics® ICUsupports gut health and can positively influence metabolic balance.

8. Athletic performance

A healthy gut microbiota improves nutrient absorption, reduces inflammation and supports immunity.
This leads to better energy availability, faster recovery and improved performance.

👉 GoldBiotics® ICU contributes to maintaining a healthy gut microbiome.

9. Reproductive health

Dysbiosis can negatively affect fertility through hormonal balance, immunity and overall health.

• Females (bitches/queens): Supporting gut flora during pregnancy and lactation improves gut development in puppies/kittens and reduces diarrhoea.

• Males (stud dogs/toms): Disturbed gut flora may impair sperm quality and fertility.

👉 GoldBiotics® ICU supports reproductive health in both males and females.

Prebiotics

Specially selected prebiotics metabolised at different locations throughout the gastrointestinal tract.
This results in a significantly broader and more effective action than standard fibres.

Prebiotics are plant-derived molecules that selectively nourish beneficial gut bacteria and inhibit harmful flora.
Important distinction: most dietary fibres are not true prebiotics, as they also feed pathogenic bacteria.

Postbiotics

Fragments of probiotics that have been fermented in vitro, neutralised and then highly concentrated.
They often consist of cell wall components of probiotics, which exert a strong prebiotic effect.

In GoldBiotics® ICU, the concentration of postbiotics is hundreds of times higher than the amount normally produced in vivo during probiotic breakdown.

Fatty acid glycerol ester

• Supports the intestinal barrier and helps suppress intestinal inflammation.

• Strengthens immune defence against pathogenic organisms.

• Stimulates the intestinal lining to produce microRNAs that promote gene expression and the growth of healthy gut flora.

Optimal dosages

Each dose for a medium-sized dog provides more than 5 g of prebiotic effect.
This exceptionally high dosage makes GoldBiotics® ICU unique in both efficacy and effectiveness.

Proven results

Internal research with GoldBiotics® ICU demonstrated an increase of up to 60% in volatile fatty acid (VFA) production.

VFAs are the most important indicator of gut health and microbial activity.

Probiotics are theoretically beneficial but foreign microorganisms that are administered alive. However, they present several important disadvantages:

• With 10⁹ CFU (already considered a high daily dose), only 0.000000001 g is administered to a total microbiota mass of ~100 g. The impact is therefore extremely limited.
  In contrast, GoldBiotics® ICU delivers 5 g of active compounds per dose.

• Despite thousands of (often sponsored) studies, there is little to no solid evidence of lasting benefits from probiotics.

• Trials in foals even had to be stopped early due to negative effects.

• The gut microbiome is an extremely refined ecosystem; foreign microorganisms rarely establish themselves sustainably.

• After antibiotic treatment, probiotics often hinder microbiome recovery rather than support it.

• Many supplements contain contaminants or far fewer viable organisms than stated on the label.

• When benefits do occur, they are usually due to minor prebiotic effects of probiotic breakdown products, not the organisms themselves.

Pre- and postbiotics are hundreds of times more effective and safer in supporting the existing ecosystem.

Example: live yeast (Saccharomyces), one of the most commonly used probiotics, carries multiple risks:

• competition with native flora for nutrients and space

• alteration of gut pH and environment

• risk of overgrowth (candidiasis, fungal infections)

• immune reactions and inflammation

• potential transfer of antibiotic resistance genes

• reduced effectiveness of other gut-supporting supplements

Conclusion: Unlike probiotics, the pre- and postbiotics in GoldBiotics® ICU provide a far more powerful, consistent and proven support for gut health.

Packaging: GoldBiotics® ICU is available in 100 ml and 300 ml bottles.
Shake well before use.

Daily dosage

• Cat & small dog (<10 kg): 5 ml/day

• Medium-sized dog (10–25 kg): 7.5 ml/day

• Large dog (>25 kg): 7.5 ml/day

👉 The price of the 100 ml bottle is deliberately kept low to remain affordable during short-term medication periods (antibiotics, NSAIDs).
For long-term support, larger packaging sizes are more cost-effective.

After the course, supplementation can be continued with COMBI GOLD, which contains a lower yet still effective dose of GoldBiotics® ICU.