GOLDBIOTICS ICU EQUINE

There is a wealth of scientific evidence that intestinal flora plays an important role in sports performance. For example, healthy intestinal flora can contribute to better absorption of nutrients, a reduction in inflammation and better regulation of the immune system. This in turn can improve energy production and muscle recovery, leading to better performance. Other studies point to the microbiome-mitochondria link as one of the most efficient ways to increase cardiovascular capacity. It is also true that the microflora itself can supply up to 70% of the horse’s required energy through volatile fatty acid production. A link between the individual composition of the flora and performance in racehorses was also established.

Our own research with GOLDBIOTICS ICU EQUINE showed an increase of volatile fatty acid production of 60%.

Medical treatment or surgery usually requires medication to be administered.
Most medications (cf. study in Nature also on 1,000 non-antibiotics), but certainly antibiotics, NSAIDs, stomach medications, etc. have a catastrophic effect on the intestinal flora and therefore on the beneficial influence of the intestinal flora on the body. Recovery can take months.
Administering GOLDBIOTICS ICU EQUINE, preferably a few days before, but certainly during and after the treatment period, will largely limit this damage.

A horse’s intestinal flora plays an important role in the digestion process and the formation of manure. Healthy intestinal flora ensures efficient breakdown of nutrients and optimal water absorption, resulting in a normal consistency and color of the manure.

If a horse’s intestinal flora becomes out of balance, this can lead to poorer digestion of food, which can lead to diarrhea or constipation. This can then result in a change in the consistency and odor of the manure. For example, the manure may be watery or thinner than normal, or drier and harder than normal.

In addition, unhealthy intestinal flora can lead to the production of gases and toxic substances in the intestines, which can also affect the quality of the manure. This can, for example, lead to a strong and unpleasant odor in the manure.

Eating sand, also known as geophagia, can lead to health problems such as colic and constipation because sand can build up in the intestines and disrupt the normal functioning of the gastrointestinal tract.

Research has shown that unhealthy intestinal flora, especially a lack of fiber and beneficial bacteria, can lead to an increased risk of sand eating in horses.

This can lead to slow bowel movement and constipation, making horses more likely to eat sand or soil to relieve the blockage. The risk of sand eating can be reduced by choosing the right food and supporting the flora.

Research has shown that there is a link between the intestinal flora and the brain, via the so-called gut-brain axis. The intestinal flora communicates with the brain via nerve signals, hormones and other means of communication, which can lead to changes in the behavior of horses.

An unhealthy intestinal flora can lead to increased stress levels in horses, resulting in anxious, aggressive or depressive behavior. In addition, unhealthy intestinal flora can lead to poor absorption of nutrients, which can result in deficiencies that affect the behavior and mood of horses.

On the other hand, promoting healthy intestinal flora, for example by giving prebiotics, can improve the mood and behavior of horses, show less stress and be less sensitive to stressful situations. Also improving nutrient absorption can lead to improved concentration and alertness, which can be beneficial for horses involved in sports and other performance-oriented activities.

Skin: Unhealthy gut flora can lead to an increased inflammatory response in the body, which can lead to skin problems such as itching, rashes, eczema and infections. In addition, unhealthy intestinal flora can contribute to the development of food allergies and intolerances, which can also lead to skin problems.

Conversely, promoting healthy intestinal flora through prebiotics can contribute to healthy skin in horses. Studies have shown that these can help reduce inflammation and promote a healthy immune response, which can lead to healthier skin in horses.

Joints/cartilage: Recently, a cartilage gutmicrobiome axis has been scientifically discovered. Gut microbiota DNA was found in synovium of osteoarthritis and rheumatoid arthritis. This suggests that a connection takes place of dead or living bacteria from intestinal microbiota and the epiphysis-bone marrow. Subchondral microbiota can enhance cartilage healing and transform components of the deep cartilage matrix into metabolites with immunosuppressive properties.

On the other hand, it was also shown that prebiotics, which promote Actinobacteria, including Bifidobacteria, beneficially modify the microbiome, thereby providing protection against osteoarthritis in an obesity-situation. It was already known that beneficial changes to the microbiome generally reduce its pro-inflammatory influence and strengthen its anti-inflammatory signals.

Liver: The intestines and liver work closely together and are interconnected through the so-called “porta hepatis,” a major blood supply to the liver.

An imbalance in the intestinal flora can lead to increased permeability of the intestinal wall and increased absorption of toxins and endotoxins in the blood. This can lead to inflammatory processes and oxidative stress in the liver, which can ultimately lead to liver damage and even liver failure.

GOLDBIOTICS ICU EQUINE contains ingredients that support the intestinal wall

Research has been conducted into the effects of prebiotics on the liver health of horses. These studies show that adding prebiotics to the diet of horses can contribute to a reduction of inflammatory processes and oxidative stress in the liver. This can ultimately lead to better liver health and a reduced risk of liver disease.

Several studies have shown a link between intestinal flora composition,  insulin resistance and metabolic syndrome in horses. An unhealthy intestinal flora can contribute to inflammatory processes and increased permeability of the intestinal wall, as a result of which substances can enter the bloodstream that have a negative effect on the horse’s metabolism.
GOLDBIOTICS ICU EQUINE contains ingredients that support the intestinal wall
Adding prebiotics and probiotics to the diet can help reduce inflammatory processes and improve insulin sensitivity, which can reduce the risk of developing metabolic syndrome.

In addition, studies have also been done on the effects of prebiotics on laminitis and insulin resistance. These studies show that adding prebiotics to the diet of horses can contribute to improved insulin sensitivity and a reduced risk of laminitis.

There is some evidence that intestinal flora may play a role in the development of PPID in horses. It has been shown that horses with PPID have a different composition of intestinal flora than healthy horses. Adding prebiotics to the diet can help reduce inflammatory processes and improve resistance to infections, which can contribute to better health in horses with PPID.

Inflammatory Bowel Disease (IBD) is an inflammatory disease of the gastrointestinal tract that often occurs in horses. IBD is characterized by chronic inflammation and damage to the intestinal wall, which can lead to symptoms such as diarrhea, weight loss, and poor food absorption.

Much research has been done into the role of intestinal flora in IBD in horses. These studies show that disturbances in the intestinal flora, such as reduced diversity and overgrowth of pathogenic bacteria, can contribute to the onset and progression of IBD.

Disrupted intestinal flora can lead to increased permeability of the intestinal wall, which can lead to the leakage of endotoxins and other harmful substances into the blood. This can lead to a systemic inflammatory response, where the horse’s immune system becomes overactive and causes inflammation in different parts of the body.

GOLDBIOTICS ICU EQUINE contains ingredients that support the intestinal wall

Much research has been done into the role of intestinal flora in inflammatory diseases in horses, such as colic, diarrhea, and laminitis. These studies show that adding prebiotics can contribute to reducing inflammatory processes in the body. This can ultimately lead to an improvement in the horse’s overall health and well-being.

A 2018 study examined the composition of intestinal flora in mares and its possible influence on fertility. The results showed that mares with a more diverse intestinal flora had a better chance of becoming pregnant than mares with a less diverse intestinal flora. Another 2019 study examined the effects of prebiotics on the reproductive performance of mares. The results showed that the mares that received the prebiotic had a higher ovulation frequency and took a shorter time to conceive than the mares that did not receive the prebiotic.

A mixture of prebiotics, where we have chosen products that are metabolized in different places throughout the entire length of the intestinal tract, making the effect many times more favorable
As a reminder, prebiotics are usually plant molecules that selectively favor the beneficial flora of the host as a nutritional source and directly or indirectly harm the unfavorable ones. Most fiber is not a prebiotic because it provides a food source for both beneficial and unfavorable flora.

More information about prebiotics

. A mixture of postbiotics. Postbiotics are prebiotic fragments of probiotics that have been fermented in vitro and subsequently neutralized and enriched. It is usually the cell walls of the probiotics that have the prebiotic effect. The amount of postbiotics that are supplied through GOLDBIOTICS ICU EQUINE is hundreds of times higher than the postbiotics that are created in vivo due to the breakdown of the commonly used probiotics.
. Fatty acid ester of glycerol. It has been shown to support the intestinal wall, suppress inflammation in the intestine and boost the immune system against disease-causing organisms. In addition, the intestinal wall produces microRNAs that promote the expression of genes and growth of healthy intestinal flora.
. More than sufficient amounts of the previous 3. One daily dose for a horse contains more than 25 g of prebiotic effect.
Proprietary research with GOLDBIOTICS ICU EQUINE demonstrated an increase of up to 60% in volatile fatty acid production.

Probiotics are theoretically beneficial but foreign microorganisms that are administered “live” through food. But…

. Despite thousands of  “sponsored(!)” studies, there are  few, if any, that demonstrate beneficial effects on the host

. Trials on foals had to be stopped due to the adverse effects.

. The microflora ecosystem in the intestines is so refined that it is very difficult for these foreign organisms to establish themselves (and only after months/years) or never.

. In contrast to the protective effect of prebiotics, the recovery of the microbiome after taking antibiotics is complicated by the administered probiotics.

. They are often contaminated with other microorganisms that are not listed on the label

. Research shows that most probiotic supplements (including well-known brands) contain far fewer organisms than claimed on the label

. If there is any effect, it is caused by the (small) prebiotic effect of the breakdown products of the probiotics.

. Using pre- and postbiotics  to support the existing ecosystem is hundreds of times more efficient.